By default, the work profile is isolated from the personal profile. Applications, data, and accounts in one profile cannot access those in the other. This is the foundational privacy and security guarantee of the work profile model.
However, administrators can selectively relax this boundary using cross-profile policies. The level of control depends on whether the device is personally-owned (BYOD) or company-owned (COPE).
What can be configured
BYOD vs COPE differences
On personally-owned work profiles, the default cross-profile restrictions are more permissive toward the user - for example, sharing from personal to work is allowed by default. On company-owned (COPE) devices, administrators have broader control and can lock down both directions.
Cross-profile loopback traffic blocked (Android 17)
From Android 17, apps can no longer use localhost (127.0.0.1) to communicate across profiles. This applies to all apps regardless of target API level, and there is no administrator opt-out. Apps that previously relied on loopback calls between the personal and work profile - such as identity providers using local callbacks for authentication - will fail. The most prominent example is Okta Verify FastPass, which uses loopback-based invocation and must now be installed within the same profile as the apps it authenticates. See What enterprise features are new in Android 17? for broader context.
Best practices
For more on work profile architecture, see What is an Android work profile?.